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Welcome to your 20s — the decade when many of us start getting serious about skin care. You’ve probably got the basics down with sunscreen and moisturizer, but now is also a good time to level up your skin care game with retinol, a vitamin A derivative that tackles signs of hyperpigmentation, aging and acne.
If, however, you are new to retinol and aren’t sure how to use it, consider this your guide to everything to know about this skin care powerhouse.
Dr. Susan Massick, MD, a board-certified dermatologist at The Ohio State University Wexner Medical Center, explains that retinol is used to improve skin texture and reduce fine lines and wrinkles through increased cell turnover. She says, “It also enhances skin firmness by promoting collagen production.”
Ahead, skin care pros share how to use retinol, what percentage is just right for those in their 20s, as well as things to keep in mind as you look for the best products for a range of skin types and concerns.
Why should you start using retinol in your 20s?
According to Dr. Saami Khalifian, MD, a double board-certified dermatologist and the founder of SOM Aesthetics, starting retinol during your twenties is an excellent way to start a proactive (or “prejuvenation”) skin care approach.
“By incorporating retinol early on, you can foster long-term skin wellness and prevent premature aging,” he states.
Khalifian continues, “Retinol is effective for managing acne while also refining skin texture in your twenties. It also helps create a smoother skin surface, leading to better texture overall, diminished fine lines and a more consistent skin tone.”
The best retinol for your 20s, according to experts and editors
For oily skin: Versed Press Restart Gentle Retinol Serum

What we like
- Encapsulated retinol
- Formulated for sensitive skin
Retinol type: Microencapsulated retinol | Retinol strength: N/A | Other ingredients: Bakuchiol, shea butter, antioxidants and anti-inflammatories | Skin type compatibility: Sensitive skin, mature skin, normal skin and first-time retinol users | Format: Serum
For individuals dealing with oily and acne-prone skin, Dr. Kristina Collins, MD, FAAD, a board-certified dermatologis, recommends this affordable retinol serum. It quickly absorbs into the skin and works to prevent breakouts before they happen.
“This is a fast-absorbing, lightweight retinol serum enriched with encapsulated retinol and natural extracts designed to combat acne and shine while keeping pores clear,” she states.
Brendan Camp, MD, FAAD, recently told Shop TODAY that encapsulated retinols “slowly release active ingredients over time,” making them a bit less potent.
Editor favorite: Neutrogena Retinol Face Oil .3% Concentrated, Rapid Wrinkle Repair

What we like
- Lightweight formula
- Leaves face feeling smooth
Retinol type: Pure retinol | Retinol strength: 0.3% | Other Ingredients: N/A | Skin type compatibility: All | Format: Serum
Emma Stessman, a 28-year-old writer at Shop TODAY, recommends this tried-and-true retinol for beginners. She says that it’s “gentle enough as to not cause those unwanted effects, but still strong enough that I notice a difference in my skin! The oil feels super moisturizing, so it’s great for my dry skin.”
Sensitive-skin friendly: Neutrogena Rapid Wrinkle Repair Retinol Regenerating Cream

Something to note
- May be rough on sensitive skin
Retinol type: Accelerated Retinol SA (stabilized retinol) | Retinol strength: N/A | Other Ingredients: Hyaluronic acid, glycerin, dimethicone, vitamin C (ascorbic acid) | Skin type compatibility: All | Format: Cream
Dr. Corey L. Hartman, a board-certified dermatologist, recommends this retinol product as a great daily option that won’t break the bank. Its creamy texture feels like a rich night cream and is chock full of hydrating ingredients.
“Along with retinol, it contains hyaluronic acid, which helps keep your skin hydrated and combats any potential dryness,” he explains.
For dry skin: First Aid Beauty FAB Skin Lab Retinol Serum 0.25%

What we like
- Suitable for dry skin
- Gentle and fragrance-free
- Softens fine lines, wrinkles
Something to note
- Has an 18-month shelf life
Retinol type: Pure retinol | Retinol strength: 0.25% concentration | Other ingredients: Peptides, hyaluronic acid, vitamins C, and ceramides | Skin type compatibility: All skin types | Format: Serum
If you have dry skin, Collins says that this retinol serum is gentle enough to deliver results without irritation.
“This is a gentle, fragrance-free formula with hyaluronic acid, vitamin C and ceramides to provide anti-aging benefits without drying out the skin,” she suggests.
However, users should be aware that this retinol has a limited shelf life of 18 months, and it’s essential to store it in a cool, dark place in order to prevent degradation.
Vegan option: Biossance Squalane + Retinol Night Serum

What we like
- Hydrating
- Gentle and non-irritating
- Vegan-friendly
Retinol type: Encapsulated duo of time-release retinol and retinal | Retinol strength: N/A | Other ingredients: Squalane, glycerin and allantoin | Skin type compatibility: All including sensitive | Format: Serum
Powered by a plant-derived retinol alternative and squalane, Collins says that this serum is perfect for those seeking a clean and gentle product.
“It supports skin renewal while maintaining hydration and reducing the risk of irritation,” she explains.
For combination skin: Paula’s Choice 0.3% Retinol + 2% Bakuchiol Treatment

What we like
- Refines skin texture
- Gentle formulation
- Lightweight and easy to apply
Retinol type: Pure retinol | Retinol strength: 0.3% | Other ingredients: 2% Bakuchiol, ceramides, hyaluronic acid | Skin type compatibility: All | Format: Cream/lotion
Since combination skin has both oily and dry areas, Collins recommends this balancing retinol treatment. It not only offers a gentle formulation but is also packed with ingredients that help boost the skin
“It combines retinol with bakuchiol, peptides and antioxidants to refine skin texture without excessive irritation,” she says. “It is also lightweight and easy to apply.”
However, some user reviews indicate the retinol strength is strong, so it is important not to use more product than directed and to use a moisturizer in conjunction with this product.
Editor and expert approved: Shani Darden Retinol Reform Treatment Serum

What we like
- Hydrating ingredients
- Non-drying
- Non-irritating
Retinol type: Encapsulated Retinol | Retinol strength: 2.2% encapsulated retinol | Other ingredients: Niacinamide, lactic acid (AHA) and tocopheryl acetate (vitamin E) | Skin type compatibility: Normal, combination and oily skin | Format: Serum
Many retinol products can lead to dryness, so if you’re in search of a more moisturizing option, Collins suggests trying this serum.
“This serum blends gentle, slow-release retinol with lactic acid and hydrating ingredients,” she explains. “It smooths texture and boosts radiance without excessive dryness or irritation.”
However, some user reviews indicate that this serum may not effectively lighten dark spots, even when used regularly.
Madison San Miguel, an editorial assistant at Shop TODAY, also recommends this product. She says, “I used Trentinoin when my acne was severe as a teen, but I always had to use the smallest amount because it can be harsh. Since then, my kin has become a bit sensitive to retinol, but this one from Shani Darden has been a game-changer.”
She continues, “It’s incredibly gentle and non-drying, so it is a great choice for someone new to retinol or with dry/sensitive skin (like myself!). I’m in my mid-twenties, which is when you should start using retinol, and think this is is a great choice for preventation, too. I always notice my skin looks and feels a lot smoother the day after I use it, so I can imagine the long-term results!”
Beginner-friendly option: Mother Science Retinol Synergist

What we like
- Treats hyperpigmentation
- Softens fine lines, wrinkles
- Gentle formulation
Retinol type: Encapsulated retinol | Retinol strength: N/A | Other ingredients: Malassezin, ceramides and tocopherol (vitamin E) | Skin type compatibility: All skin types | Format: Serum
Harman recommends this particular retinol for those just starting out due to its gentle formulation and carefully selected ingredients.
He explains that the Mother Science Retinol Synergist combines retinol with Malassezin, which effectively addresses issues like hyperpigmentation, uneven skin tone and signs of aging such as fine lines and wrinkles. “Research indicates that Malassezin not only soothes the skin but also enhances the skin barrier, which can help shorten the adjustment period when using retinol,” Hartman says.
Although this serum is pricier than many other retinols on the market, Hartman believes it remains an excellent choice for newcomers to retinol or individuals with sensitive skin who may have struggled with other retinol products in the past.
Infused with aloe vera extract: Monastery Healing Botanical Skincare™

What we like
- Gentle
- Hydrating
- Boosts collagen
Retinol type: Retinol | Retinol strength: N/A | Other ingredients: Aloe vera leaf extract, reishi, rose, radish root | Skin type compatibility: All skin types | Format: Cream
Erica Marrison, a partnerships editorial assistant at Shop TODAY, recommends this retinol cream. She says, “I recently had my first appointment with a dermatologist and she confirmed what I’d always known: My skin is sensitive. Because of that, I have to be careful with retinols — many of them are just too harsh for me.”
She continues, “That said, I love this one by Monastery, which leaves my skin feeling so smooth and dewy (but not oily) in the morning, with no visible signs of redness. I apply it every second nights because, right now, every night is too often. I love that I can really see the brightening and hydrating effects; no other serum has ever given me such clear results so fast. It’s definitely expensive, but I’ve been using it for six months and I still have half of the bottle left. I apply it after my essence and Dapsone acne prescription, but before my moisturizer.”
For acne-prone skin: SkinBetter AlphaRet Clearing Serum

What we like
- Gentle on skin
- Dermatologist-tested
- Combines retinol with AHAs
Retinol type: Ethyl Lactyl Retinoate (AlphaRet Technology) | Retinol strength: N/A | Other ingredients: Salicylic acid, lactic acid and niacinamide | Skin type compatibility: Oily, acne-prone, and combination | Format: Serum
For individuals with acne-prone skin, Hartman recommends a dermatologist-tested retinol serum that does not contain parabens, fragrances or dyes.
“This is one of my favorite options for managing acne without irritation,” Hartman explains. “I’m particularly fond of SkinBetter’s AlphaRet technology because it combines retinol with AHAs. This powerful mix helps reduce fine lines and wrinkles while improving overall skin texture and tone.”
What to look for while shopping for retinol in your 20s
When selecting the right retinol product for your skin, there are a few key factors to consider.
These include the type and strength of retinol, how well it matches your skin type, and any additional ingredients in the formulation. Understanding why each of these aspects matters is essential for making an informed choice. Here’s why:
Retinol type
There are different types of retinols used in skin care products. For most people in their twenties, sticking to over-the-counter (OTC) options like retinol or retinaldehyde is a smart move since they’re milder while still delivering results.
“Over-the-counter options like retinol and retinaldehyde typically come in creams or serums, while prescription-strength retinoic acid — such as tretinoin or tazarotene — is usually found in gel or cream form,” Massick explains.
Again, for those in their twenties, Massick recommends using OTC retinol or retinaldehydes. However, she also advises against overusing anti-aging products to avoid removing essential oils from the skin, which can result in dryness and irritation.
Retinol strength
Dr. Anna Chacon, MD, a board-certified dermatologist, emphasizes that retinol strength plays a critical role when choosing between serums, creams or treatments.
She advises: “Starting with a concentration of 0.1%–0.2% is generally safe for beginners, but consulting a dermatologist ensures personalized recommendations for optimal outcomes.” She adds, “Begin with lower concentrations and gradually increase usage after patch-testing to minimize irritation.”
Additional ingredients
When using skin care products that contain retinol, it’s crucial to pay attention to the other ingredients included.
Since retinol is a potent component, you should seek out products that also feature hydrating and barrier-supporting ingredients. According to Melanie Speed, APRN, NP-C, CANS, MSN, a nurse practitioner and the founder of Flawless MedSpa, “This combination helps reduce irritation and keeps your skin balanced.”
Skin type compatibility
Your skin type plays a big role in selecting the right retinol product. As Chacon points out, “Since everyone’s skin is different, a tailored consultation is highly recommended, especially if you’re dealing with any skin conditions.”
Format or texture
Retinols come in a variety of forms and textures, including creams, serums, gels and oils.
For those with skin in their twenties, Chacon suggests using serums because they mix well with other skin care products.
“I really recommend using a serum,” she explains. “Using a serum underneath your moisturizer can enhance the benefits while reducing the risk of dryness that sometimes comes with added products. However, it’s important to remember that results can vary depending on the brand and your individual skin type and preferences.”
How should I add retinol in my skin care routine?
To use retinol correctly, Massick recommends a simple approach: “Start low and go slow.”
“This means you should begin by applying it to a small area of your skin to check for any sensitivity,” she explain. “Start using retinol once or twice a week, and then gradually increase the frequency as your skin adjusts. By taking this gradual approach, you can help prevent common side effects like dryness and irritation.”
As you incorporate retinol into your skincare routine, Massick emphasizes the importance of pairing it with other products.
She advises, “Use a gentle cleanser twice daily, apply a broad-spectrum sunscreen with an SPF of 30 or higher every morning (and reapply throughout the day as needed), and use a moisturizer to keep your skin hydrated.”
Meet the experts
- Dr. Susan Massick, MD, is a board-certified dermatologist at The Ohio State University Wexner Medical Center.
- Dr. Saami Khalifian, MD, is a double board-certified dermatologist and the founder of SOM Aesthetics.
- Dr. Shayan Cheraghlou, MD, FAAD is a board-certified dermatologist.
- Melanie Speed, APRN, NP-C, CANS, MSN, is a nurse practitioner and the founder of Flawless MedSpa.
- Corey L. Hartman, MD, FAAD, is a board-certified dermatologist.
- Dr. Kristina Collins, MD, FAAD, is a board-certified dermatologist.
- Dr. Anna Chacon, MD, is a board-certified dermatologist.
- Brendan Camp, MD, FAAD, is a New York-based double board-certified dermatologist.